Role of corticotropin releasing factor in anxiety disorders: A translational research perspective
نویسندگان
چکیده
منابع مشابه
The role of corticotropin-releasing factor in depression and anxiety disorders.
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the evidenc...
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colors used by Brouwer and Heeger. Colors are of equal luminance and saturation, and vary only in hue. As depicted in the image, these colors form a circular color space, matching the perception of similarity between these colors of human observers: the organization of the colors form a logical progression through color space, from red, to orange, yellow, green, blue, purple and back to red. Re...
متن کاملThe potential role of a corticotropin-releasing factor receptor-1 antagonist in psychiatric disorders.
CNS Spectr 13:6 June 2008 467 NEW TREND IN PSYCHOPHARMACOLOGY The hypothalamic-pituitary-adrenal axis is a key mediator of the stress response in humans. The corticotropin-releasing factor (CRF) type 1 receptor (CRFR-1) in the pituitary gland is a gatekeeper for that response, and the CRFR-1 receptor is also present in many other moodand cognition-related neural structures. Behaviorally, a numb...
متن کاملThe role of corticotropin-releasing factor receptors in stress and anxiety.
Corticotropin releasing factor (CRF) is a critical integrator of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. CRF and its related molecule urocortin (UCN) bind CRF receptor 1 (CRFR1) and CRFR2 with distinct affinities. Mice deficient for CRFR1 or CRFR2 were generated in order to determine the physiological role of these receptors. While CRFR1-mutant mice show a depleted ...
متن کاملCognitive disruptions in stress-related psychiatric disorders: A role for corticotropin releasing factor (CRF).
This article is part of a Special Issue "SBN 2014". Stress is a potential etiology contributor to both post-traumatic stress disorders (PTSD) and major depression. One stress-related neuropeptide that is hypersecreted in these disorders is corticotropin releasing factor (CRF). Dysregulation of CRF has long been linked to the emotion and mood symptoms that characterize PTSD and depression. Howev...
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ژورنال
عنوان ژورنال: Hormones and Behavior
سال: 2006
ISSN: 0018-506X
DOI: 10.1016/j.yhbeh.2006.06.019